Association of Psilocybin Use in Adolescents with Major Depressive Episode

Result: increase risk of major depressive episode “We identified a significant association between psilocybin use and MDE among adolescents, which raises public health concerns about its illegal use, abuse, and toxicity potential. Future clinical studies should assess its clinical safety, efficacy, and addictive properties.”

https://pmc.ncbi.nlm.nih.gov/articles/PMC9563652/

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Early-onset Psychosis Associated to Hallucinogen Use in Adolescents: a systematic review and meta-analysis

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Adverse Outcomes Following Psychedelic Use in Adolescents